§ II·Evidence-based, body-weight-scaled, lab-personalized

Supplements

11 evidence-based dosing calculators; body-weight-scaled, lab-personalized, with the source paper linked on the same screen.

SUP-01 · Body-weight-scaled

Creatine Loading Calculator

0.3 g/kg load, 0.03 g/kg maintenance. Load-then-maintain or direct-maintenance; both end at the same saturation. Serum creatinine rise is the marker, not kidney damage.

500+ RCTs · ISSN-aligned

SUP-02 · Lab-baseline personalization

Vitamin D3 Dose-to-Target

Daily IU from your 25(OH)D baseline, target, and body weight. Cofactor rules for K2 + magnesium.

Heaney serum-dose model

SUP-03 · Goal-based · form picker

Magnesium Dosing Calculator

Elemental mg range + split schedule + recommended form (glycinate, threonate, citrate, taurate, malate) by goal. UL flagged automatically.

600+ enzymatic cofactor reactions

SUP-04 · Ferritin-to-repletion

Iron Deficiency Calculator

Personalized oral iron dose, form, and schedule from your ferritin, sex, and indication. Daily vs alternate-day per the 2026 RCT. Stops on overload, gates on occult-bleed risk.

Severity-aware · GI-workup gate

SUP-05 · Goal-based · copper-offset gated

Zinc Dosing Calculator

Elemental zinc dose, form (bisglycinate / picolinate / acetate lozenge), and copper-offset rule from your goal, sex, diet, and duration. Cold lozenges within the 24 h window only; intranasal zinc contraindicated.

Cold lozenge 24 h window · UL-aware

SUP-06 · Goal-based · metformin-screen aware

Vitamin B12 Dosing Calculator

Goal, diet, metformin exposure, and form preference drive your B12 dose. Refuses to dose replete omnivores per the 2025 Mendelian randomization. Annual-screen flag at 4-year metformin exposure (CUBN rs1801222 modifier).

MR-null in replete adults · ADA 2026 screen

SUP-07 · Bioavailability-adjusted · AF-gated

Omega-3 Dose-to-Index Calculator

EPA+DHA dose with bioavailability-adjusted absorbed mg from goal, formulation (rTG / TG / EE / krill / algal), and meal context. AF cap at 4 g/day for users with prior atrial fibrillation history.

REDUCE-IT + Cochrane + PISCES NEJM 2026

SUP-08 · Diet-first · CVD-flag aware

Calcium Dietary-Gap Calculator

Life-stage RDA target, dietary intake estimate from dairy + leafy + fortified foods, supplemental gap split at ≤500 mg/dose. Hard CVD flag for diabetic supplementers (Qiu 2024 HR 1.67); amber flag at >1000 mg/day supplemental in non-diabetics (Chen 2025 + Reid 2025).

Reid 2025 + UK Biobank diabetic + AF signal

SUP-09 · Goal × form × VKA-aware

Vitamin K2 Dosing Calculator

Goal, form (MK-7 vs MK-4), warfarin/VKA status, and high-dose D3 context drive a vitamin K2 protocol. Refuses to dose VKA users; null-benefit on healthy adults without D3 stack; surfaces the AVADEC null primary endpoint and the Binkley 2009 Western replication failure of the Japanese MK-4 fracture protocol.

AVADEC honest · Western-replication-null flagged

SUP-10 · ACOG · USPSTF Grade A · Cochrane MA

Folate Preconception Risk-Stratified Calculator

Five inputs — prior NTD pregnancy, BMI, diabetes, AED therapy, MTHFR C677T — drive single-gate risk tiering (any one factor → 4000–5000 µg/day) and form selection (folic acid default; 5-MTHF for MTHFR TT and AED users). 3-month preconception lead time, gestational week 12 cutoff, mandatory B12-precheck for high-risk doses.

Single-gate risk tiering · MTHFR-aware · B12-precheck

SUP-11 · Goal × bedtime × CYP1A2-aware

Melatonin Dose & Timing Calculator

Goal (sleep onset / jet lag / DSPS / elderly), bedtime, CYP1A2 status, and T2DM context drive a melatonin protocol — dose, IR vs PR, and the exact clock time to take it. Floors slow CYP1A2 metabolizers at 0.3–1 mg. Surfaces the Lauritzen 2022 T2DM insulin-sensitivity signal. Form-mismatch flag fires for PR-on-jet-lag and PR-on-DSPS.

Dose-response paradox honest · 0.3 mg ≈ 5 mg