Calculator Methodology
Every calculator's formula, source papers, assumptions, and limits; documented openly so you can audit the math before trusting the result. Same PubMed-verification standard as the calculators themselves.
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/creatine-loading-calculator
Creatine Loading: Body-Weight-Scaled Math, Explained
The creatine loading calculator scales the ISSN-aligned protocol to your body weight: 0.3 g/kg/day across four doses for 5–7 days, then 0.03 g/kg/day for maintenance. Here is the formula, the evidence behind those numbers, and where the math stops being safe to extrapolate.
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/hair-loss-protocol-calculator
Hair Loss Protocol: Demographic-Aware Finasteride + Minoxidil Logic
The calculator branches on sex and androgenetic-alopecia stage to pick a finasteride and minoxidil protocol; male AGA gets oral 5-AR inhibition plus topical minoxidil, premenopausal women get topical-only, postmenopausal women open the systemic options. Built on the AGA RCT and meta-analysis evidence base, not on hair-clinic marketing copy.
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/iron-deficiency-calculator
Iron Deficiency Protocol: Ferritin-to-Repletion Math
The iron calculator picks dose, form, and schedule from your ferritin, sex, and indication, with a hard GI-workup gate for men and post-menopausal women. Here is the dosing logic, the daily-vs-alternate-day evidence, and why the calculator refuses to dose some users.
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/magnesium-calculator
Magnesium: Goal-Based Dose and Form Selection
How the calculator picks both a daily dose and a specific magnesium form by goal, and why every output is reported in elemental milligrams rather than milligrams of compound.
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/omega-3-calculator
Omega-3 Dosing: Bioavailability-Adjusted EPA + DHA Across Formulations
The omega-3 calculator picks dose, formulation, and AF cap from your goal and meal context. The unique signal is the absorbed mg after bioavailability adjustment — re-esterified TG with food delivers about 85% of the label dose; ethyl ester on a low-fat meal drops to roughly 30%. The same number on the bottle can be 2–3x apart in physiological exposure.
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/compounds
Our Review Methodology
Every compound monograph on Apotheon ends with a Practical Verdict — a calm, evidence-anchored summary of what the research actually supports versus what's hyped. Here is how each monograph is built, vetted, and cited.
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/peptide-calculator
Peptide Reconstitution: How the Math Works
The arithmetic behind the peptide reconstitution calculator: how vial mass, bacteriostatic water volume, and target dose resolve into a concentration, an insulin-syringe unit count, and a doses-per-vial figure, with the assumptions and limits made explicit.
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/retatrutide-dosage-chart
Retatrutide Dose Escalation: How the Schedule Works
Retatrutide is an investigational triple GIP/GLP-1/glucagon agonist. The calculator mirrors the Phase 2/3 escalation Lilly used in TRIUMPH (2 → 4 → 8 → 12 mg weekly) and surfaces what's still open.
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/semaglutide-dosage-chart
Semaglutide Dose Escalation: How the Schedule Works
The FDA-approved semaglutide escalation steps from 0.25 mg to 2.4 mg weekly in 4-week increments. The chart documents the label schedule. It does not replace prescriber judgment, model individual GI tolerability, or cover compounded supply.
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/tirzepatide-dosage-chart
Tirzepatide Dose Escalation: How the Schedule Works
The arithmetic and FDA-label assumptions behind the tirzepatide dosage chart: six monthly steps from 2.5 mg to 15 mg, dual GIP/GLP-1 mechanism, and where the calculator stops being useful.
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/b12-calculator
Vitamin B12 Dosing: Repletion, Metformin Prevention, and the Replete-Adult Refusal
The B12 calculator picks dose, form, and retest schedule from your goal, diet, and metformin exposure. It explicitly refuses to dose cognitively-replete omnivores — the largest Mendelian-randomization study found null effect on cognition and 8 psychiatric outcomes from raising serum B12 in this population. Pernicious anemia is now an oral-first protocol.
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/vitamin-d3-calculator
Vitamin D3 Dosing: The Heaney Serum-Response Model, Explained
The vitamin D3 calculator uses the Heaney response coefficient (roughly 1 ng/mL serum 25(OH)D rise per 100 IU/day at 70 kg) to bridge a measured baseline to a chosen target, then scales the dose by body weight.
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/zinc-calculator
Zinc Dosing: RDA, Cold Lozenges, and the Copper-Offset Gate
The zinc calculator picks dose, form, and copper-offset rules from your goal, sex, diet context, and duration. Cold lozenges are gated to the first 24 h of symptom onset; long-term ≥25 mg/d without copper triggers the offset rule. Wilson disease and AMD are intentionally out of scope.
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