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§ HRX-01·Finasteride + minoxidil · demographic-aware

Hair Loss Protocol Calculator

Picks the evidence-based finasteride dose for your demographic plus your preferred minoxidil route (topical 5%, oral LDOM, or both). Surfaces the shedding timeline, LFT schedule, and PFS stop rules up front.

1 mg/dFinasteride FDA label · AGA−65%Scalp DHT at 2 wk · LC-MS12–18 moPeak visible effect

§ TIMELINE

What to expect, week by week

Photo-track every 3 months under identical lighting. The shedding paradox is the #1 drop-off point for users; knowing it's coming is half the battle.

  1. Weeks 2–8

    Dread shed

    Transient synchronized telogen exit. Do NOT stop; it is often a response indicator.

  2. Weeks 8–12

    Shedding slows

    Exit phase tapers as new anagen cycles begin.

  3. Weeks 16–24

    Visible density improvement

    Vertex hair counts typically +10 to +30 hairs/cm².

  4. Weeks 24–52

    Terminal regrowth

    Vellus-to-terminal conversion continues; photo tracking shows real change.

  5. Weeks 52–78

    Peak visible effect

    Maximum benefit at 12–18 months; plateau thereafter with continued use.

§ ANCILLARIES

Supplements with evidence, ranked honestly

  • Iron repletion if ferritin < 70 ng/mL · evidence: strong; Low ferritin is a well-documented contributor to telogen effluvium. Test before stacking.
  • Vitamin D3 if 25(OH)D < 30 ng/mL · evidence: moderate; Cross-sectional association with alopecia severity; see the Vitamin D3 calculator for dose.
  • Marine collagen 10 g/day · evidence: weak; Mixed evidence; safe. Pair with vitamin C.
  • Saw palmetto 320 mg/day · evidence: weak; Mild 5-AR-1 activity; not additive with finasteride. Only consider as monotherapy for cautious users.
  • Biotin · evidence: none; No evidence of benefit absent deficiency; skews thyroid/troponin lab assays. Skip unless documented deficiency.

§ MONITORING

Photos, labs, and the weekly mood log

  • Baseline photos (vertex, mid-scalp, hairline, temples) under consistent lighting + repeat at 3, 6, 12 months.
  • Optional baseline labs: total T, SHBG, DHT, TSH, ferritin, 25-OH-D; rule out non-androgenic causes.
  • Weekly mood / libido / cognitive log during weeks 1–12 (EMA/MHRA suicidal-ideation warning).
  • LFT (AST, ALT): baseline, 3 mo, annually; minor finasteride signal.
§ ReferencesFDA label · EMA PRAC · LDOM Delphi · oral-vs-topical meta-analyses
  1. 01Sobral et al. (2025): Oral vs topical minoxidil for AGA, MA of 4 RCTs N=279 (PMID 39425514)
  2. 02Sinclair R et al. (2025): Low-dose oral minoxidil (LDOM) Delphi consensus (PMID 39774750)
  3. 03Ezzat et al. (2026): JAAD review: Frontal fibrosing alopecia part II, etiopathogenesis and management (PMID 39800209)
  4. 04Finasteride FDA label; Propecia 1 mg / Proscar 5 mg (DailyMed)
  5. 05EMA PRAC 2025; Finasteride suicidal ideation warning update

§ FAQ

Dread shed, PFS, topical fin, LDOM, female safety

The dread shed is a transient synchronized telogen exit at weeks 2–8 after starting finasteride or minoxidil. It is often a response indicator; hairs in the telogen phase are being ejected to make room for new anagen growth. Do NOT stop unless you hit a different stop criterion (persistent sexual/mood/cognitive change). Expect shedding to slow by weeks 8–12 and visible density improvement by weeks 16–24.

Private feedback · goes to the maintainer

Spotted a wrong number, a missing edge case, or a citation issue? Send it. Not published anywhere.

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